Detalhe da pesquisa
1.
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Cell
; 162(1): 146-59, 2015 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26140595
2.
Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
Angew Chem Int Ed Engl
; 56(28): 8153-8157, 2017 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28544137
3.
A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.
Bioorg Med Chem Lett
; 26(15): 3436-40, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27374241
4.
Structure-driven approaches and technologies for drug discovery.
Drug Discov Today Technol
; 40: 25-26, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34916016
5.
Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.
Bioorg Med Chem
; 23(12): 2767-80, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25975640
6.
A framework for identification of actionable cancer genome dependencies in small cell lung cancer.
Proc Natl Acad Sci U S A
; 109(42): 17034-9, 2012 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23035247
7.
Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.
Angew Chem Int Ed Engl
; 54(42): 12398-403, 2015 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25908259
8.
Covalent-Allosteric Kinase Inhibitors.
Angew Chem Int Ed Engl
; 54(35): 10313-6, 2015 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26110718
9.
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
Cell Chem Biol
; 28(2): 134-147.e14, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33086052
10.
Corrigendum to "Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR" [Bioorg. Med. Chem. 23, 2015, 2767-2780].
Bioorg Med Chem
; 23(15): 5075, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32689707
11.
Proteus in the world of proteins: conformational changes in protein kinases.
Arch Pharm (Weinheim)
; 343(4): 193-206, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20336692
12.
Identification of cancer driver genes based on nucleotide context.
Nat Genet
; 52(2): 208-218, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32015527
13.
An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives.
Methods Enzymol
; 610: 191-218, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30390799
14.
Targeting protein arginine methyltransferase 5 in disease.
Future Med Chem
; 9(17): 2081-2098, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29076773
15.
Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease.
Curr Med Chem
; 24(37): 4121-4150, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28240169
16.
Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.
Cell Rep
; 20(12): 2833-2845, 2017 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930680
17.
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Sci Transl Med
; 9(394)2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28615362
18.
Identification and further development of potent TBK1 inhibitors.
ACS Chem Biol
; 10(1): 289-98, 2015 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25540906
19.
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
J Med Chem
; 58(1): 347-61, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469771
20.
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
J Med Chem
; 58(17): 6844-63, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275028